The 2022 Volta a Catalunya route features seven stages and covers 1,213.9 kilometres (754.3 mi). After the previous nine editions of the race started in Calella, the first stage started and finished in Sant Feliu de Guíxols.[7]L'Escala made its debut in the Volta as the start of stage 2.[8] That same stage, the race crossed into France, finishing in Perpignan for the first time since the 1985 edition, before re-entering Spain during stage 3.[9] Stages 3 and 4 both featured summit finishes at the ski resorts of La Molina and Boí Taüll, respectively, with the latter featuring for the first time since the 2002 edition.[10] After a flat route for stage 5, from La Pobla de Segur[11] to Vilanova i la Geltrú,[12] the Costa Daurada hosted stage 6.[13] The Volta concluded with the traditional last stage in and around Barcelona, finishing with six laps of a circuit around Montjuïc and Montjuïc Castle.[14]
After the stage, Sonny Colbrelli collapsed, fell unconscious,[20] and required emergency medical treatment before being transferred to a hospital in a conscious and stable condition for further assessments.[21][22]
On stage 2, Quentin Pacher, who was fourth in the points classification, wore the blue-striped jersey, because first-placed Michael Matthews wore the green-striped jersey as the leader of the general classification, second-placed Jonas Iversby Hvideberg wore the red-striped jersey as the leader of the mountains classification, and third-placed Sonny Colbrelli withdrew before the stage.
On stage 2, Andrea Bagioli, who was second in the young rider classification, wore the orange-striped jersey, because first-placed Jonas Iversby Hvideberg wore the red-striped jersey as the leader of the mountains classification.
On stage 3, Michael Matthews, who was second in the points classification, wore the blue-striped jersey, because first-placed Jonas Iversby Hvideberg wore the green-striped jersey as the leader of the general classification. For the same reason, Joan Bou, who was second in the mountains classification, wore the red-striped jersey, and Mattias Skjelmose Jensen, who was second in the young rider classification, wore the orange-striped jersey.
On stage 6, Juan Ayuso, who was third in the young rider classification, wore the orange-striped jersey, because first-placed João Almeida wore the green-striped jersey as the leader of the general classification and second-placed Sergio Higuita wore the Colombian national champion's jersey as the defending Colombian national road race champion.
On stage 7, Mikel Bizkarra, who was second in the mountains classification, wore the red-striped jersey, because first-placed Sergio Higuita wore the green-striped jersey as the leader of the general classification. For the same reason, João Almeida, who was second in the young rider classification, wore the orange-striped jersey.
Michael Matthews (AUS)
João Almeida (POR)
Ethan Vernon (GBR)
Richard Carapaz (ECU)
Andrea Bagioli (ITA)
Sergio Higuita (COL) 
Juan Ayuso (ESP)
Tobias Halland Johannessen (NOR)
Guillaume Martin (FRA)
Sam Oomen (NED)
Attila Valter (HUN)
Mattias Skjelmose Jensen (DEN)
Sylvain Moniquet (BEL)